Mendes' laboratory research discovered a previously unknown dual role for HSPBs in mitochondrial quality control: Cellular Condition Location of HSPBs Functional Impact / Observations Mitochondrial Intermembrane Space (IMS)

: She investigates how ATP-independent chaperones prevent the aberrant protein aggregation that often leads to disease. Mitochondrial Quality Control

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She serves as a key member of the Peripheral Neuropathy Research Group, operating under the broader umbrella of the UAntwerp µNEURO Research Centre of Excellence . This collaborative hub brings together neuroscientists and biochemists to untangle complex disorders of the nervous system. Core Research Focus: Mitochondria and Cellular Stress

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Mendes has built her advanced scientific career in Belgium, anchoring her academic and laboratory work at the University of Antwerp's Department of Biomedical Sciences .

, this study investigates biomarkers in bipolar disorder, highlighting how mitochondrial DNA changes relate to different disease states. Academic Background : She is an alumna of the

Identifying the cellular signaling signals that tell HSPBs to move (translocate) to the OMM immediately following a heat shock or stressful cellular event.

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Mendes' research looks at specific genetic anomalies, such as the , which is known to cause peripheral neuropathy. Her work demonstrates that this mutated protein incorrectly accumulates on the outer mitochondrial membrane even without heat stress, setting off a faulty signaling pathway that triggers mitochondrial failure and subsequent nerve degeneration. Institutional Contributions and Professional Networks